Structural coupling between FKBP12 and buried water
نویسندگان
چکیده
منابع مشابه
Structural coupling between FKBP12 and buried water.
Globular proteins often contain structurally well-resolved internal water molecules. Previously, we reported results from a molecular dynamics study that suggested that buried water (Wat3) may play a role in modulating the structure of the FK506 binding protein-12 (FKBP12) (Park and Saven, Proteins 2005; 60:450-463). In particular, simulations suggested that disrupting a hydrogen bond to Wat3 b...
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ژورنال
عنوان ژورنال: Proteins: Structure, Function, and Bioinformatics
سال: 2009
ISSN: 0887-3585,1097-0134
DOI: 10.1002/prot.22176